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Rebay, Ilaria
One or more keywords matched the following properties of Rebay, Ilaria
PropertyValue
keywords Transcription Factor Networks
overview The long-term goal of research in the Rebay Lab is to understand how signaling networks, cytoskeletal dynamics and tissue geometry work together to direct specific developmental decisions and programs. We use the developing Drosophila eye and heart as tractable model systems in which to explore how cell fates are specified and organized into functional tissues and organs. Our experimental approach is multidisciplinary, and incorporates molecular genetics, genomics, quantitative imaging, biochemistry and mathematical modeling. Current projects are focused on transcriptional networks and cellular mechanisms that regulate and stabilize the transition from uncommitted progenitor to specified fate and on signaling mechanisms and tissue-level biomechanical properties that together drive terminal differentiation and morphogenesis.
One or more keywords matched the following items that are connected to Rebay, Ilaria
Item TypeName
Concept Transcription Factors
Concept Gene Regulatory Networks
Concept STAT Transcription Factors
Concept Paired Box Transcription Factors
Concept Basic Helix-Loop-Helix Transcription Factors
Academic Article Biological functions of the ISWI chromatin remodeling complex NURF.
Academic Article CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE.
Academic Article Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.
Academic Article MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN.
Academic Article New vision from Eyes absent: transcription factors as enzymes.
Academic Article Signaling circuitries in development: insights from the retinal determination gene network.
Academic Article Targeting Drosophila eye development.
Academic Article The transcription factor Eyes absent is a protein tyrosine phosphatase.
Academic Article Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent.
Academic Article Ras signal transduction pathway in Drosophila eye development.
Academic Article The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.
Academic Article Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.
Academic Article Signal integration during development: insights from the Drosophila eye.
Academic Article Post-translational modifications influence transcription factor activity: a view from the ETS superfamily.
Academic Article Function of the ETS transcription factor Yan in border cell migration.
Academic Article Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.
Academic Article 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus.
Academic Article A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.
Academic Article Long-range integration of repressive and patterning inputs.
Academic Article Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila.
Academic Article Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.
Academic Article DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan.
Academic Article Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina.
Academic Article Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network.
Academic Article Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.
Academic Article Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression.
Academic Article Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.
Academic Article Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.
Academic Article A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.
Concept PAX6 Transcription Factor
Concept Heat Shock Transcription Factors
Grant Specificity and dynamics of transcriptional repression in retinal development
Grant A systems-level study of signaling networks and differentiation
Grant Cell-Cell Signaling In Embryonic and Retinal Development
Academic Article Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila.
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  • Transcription Factor
  • Networks